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Time and date: March 24, 11:15 am eastern time.

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Speaker: Ken Dill, Stony Brook University

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Title: Biophysical models of cellular adaptive forces
 
Abstract:  Cells adapt to their environments.  Perturb a cell, then let go, and it restores (homeostasis).  Or change the environment, and a cell population adapts (evolution), often described as survival of the fittest (SOF).  We model such forces: how food drives ribosomal upswitching to duplicate cells, the Warburg effect of inefficient energy usage, the speed and efficiency properties of molecular motors, and proteostasis and its collapse in cellular aging and death.  As a matter of general principle,  SOF is not so much a law of physics, like the Second-Law of Thermodynamics.  Rather, it is more like a control-system directive for maintaining balanced flows in dynamical persistence.

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